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The FB1 causes autophagic cell death in MARC-145 monkey kidney cells, and the research of FB1-induced toxicities by altered sphingolipid metabolism found that this disruption of sphingolipid metabolism is an essential first step (84)

ZahranAMAbdel-RahimMHNasifKAHusseinSHafezRAhmadABet al

Poster Presentation, Astro 61st Annual Meeting, 2019

Conversely, the extrinsic pathway of apoptosis is initiated by the binding of death ligands to death receptors, which activates downstream effector caspase-8, ultimately resulting in the activation of caspase-3, -6, and 7, thereby inducing direct cell death [94]

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