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According to the landscape document from the WHO, COVID-19 vaccine candidates generally fall into seven strategies (Box 1), which can be divided into three broad categories 44 : first, protein-based vaccines that generate target antigens in vitro such as inactivated virus vaccines, virus-like particles and protein subunit vaccines

(2014) 9:e105017

Interleukin-4 and IFN- may contribute to the development of epithelial-airway remodeling by inducing transcription factors present in antagonistic and polarized gene regulation networks in epithelial cells (132)

i.e., one that blocks release of budding virus and a second that promotes immune-mediated destruction can account for the heightened potency

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