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In a multicenter PPMI cohort, free water in the posterior region of the SN increased in de novo PD from baseline to 1, 2, and 4 years, and changes in free water within 1 year predicted changes in the Hoehn & Yahr scale at 4 years (Burciu et al., 2017)

Suggested Use For adults, take two (2) caplets twice daily, preferably with meals

Formal analysis: CN, WW

QT-ER0274 Size 48T/96T Species Rat UniProt ID P04041 Sample Type Serum, plasma, cell culture supernatant, cell lysate or tissue lysate, other biological fluid samples Detection Method Sandwich ELISA, Double Antibody Detection Wavelength OD450 Reaction Duration 120 minutes Range 31.25-2000pg/ml Sensitivity 18.75pg/ml Storage 2-8C(Sealed), Don't cryopreserve

Hashizume H, Falcn BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM