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At the onset of the psoriatic cascade, interferon- has a role in promoting the production of CCL20, IL-17 + T cells, and -defensin2 (HBD-2), which is a protein that is both antimicrobial and chemotactic in nature

The remaining authors have no conflicts to report

Theres a slight deceleration between 2017 and 2019 (risk-tolerance gap shrinking?) before COVID strikes and throws a wrench in disease models everywhere