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[13] There have also been rare reports of high-dose vitamin B (as in injectable form) precipitating skin outbreaks such as acne or rosacea in susceptible persons

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However, typically, the effectiveness of existing stem cell treatment is limited in its ability to address problems including poor implanted stem cell survival and ineffective differentiation into targeted cells (Alvarado-Velez et al., 2021)

Strict vegans and vegetarians are also at higher risk for deficiency since B12 occurs naturally only in animal-derived foods