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Body weight was recorded at baseline and on days 5, 8, and 15

Reduced renal clearance of methotrexate has been associated to increase its half-life and making leucovorin ineffective which may induce the further toxicities such as myelosuppression, mucositis and more pronounced nephrotoxicity.94 Higher plasma concentration of methotrexate significantly decreases the NADPH production and subsequent depletion of GSH that ultimately results into impaired antioxidant defense system and cellular oxidative stress.95 Jahovic et al

Glutathione: The Bodys Master Antioxidant Glutathione is one of the most important antioxidants produced by the body

Morphofunctional changes in the placenta after ozone therapy

This study found that the expression levels of steroid-synthesis-related genes Hydroxysteroid 17-beta dehydrogenase 8 (HSD17B8) and StAR-related lipid transfer domain containing 5 (STARD5) decreased significantly after DON treatment (Fig