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[40] report that oral ALA supplementation (1200 mg/12 weeks) resulted in a significant reduction in the serum leptin concentration and a noticeable elevation in the adiponectin-to-leptin ratio in patients with non-alcoholic fatty liver disease

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The Journal of Biological Chemistry , 294 (29), 1134211353

Pro-Tip: If you experience persistent nausea, eating smaller, lower-fat meals and staying well-hydrated can drastically reduce gastrointestinal discomfort while your body adapts to the delayed gastric emptying (Raja, 2025)