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Cognitive manifestations include depression, irritability, and anxiety, while GI manifestations encompass constipation, dysphagia, nausea, and prolonged intestinal transit time (Pfeiffer, 2003

Even individuals with normal B12 levels often report increased energy after receiving a B12 injection, especially those with high-stress lifestyles or frequent fatigue

Thus, given the region-specific effects of BAs and the concentration dependence of TGR5, future studies should further investigate how gut microbiota synergize with BAs and TGR5-mediated 5-HT release to regulate GI motility

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