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Since L-dopa is converted to dopamine in the CNS and the peri phery, peripheral conversion and systemic effects can be reduced by combining L-dopa with carbi dopa (a peripheral decarboxylation inhibitor), which does not cross the bloodbrain barrier

PCSK9 monoclonal antibodies (mAb) have become an important treatment for patients with hypercholesterolaemia for both primary and secondary prevention of cardiovascular disease (see Supplementary data online, Table S1 )

Data on the irritant effects of acetaldehyde on the skin and eye are restricted to those from limited studies on human volunteers

J Biol Chem 286(33):2887628888 Kinlough CL, Poland PA, Bruns JB, Hughey RP (2005) Gamma-glutamyltranspeptidase: disulfide bridges, propeptide cleavage, and activation in the endoplasmic reticulum