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The results here correlated with the binding data reported earlier, indicating that neither of the two splice variants of the hybrid receptor has a high affinity to insulin, but both have a high affinity to IGF 9 , as found in studies using tagged receptors 10

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Given the oestrogen-dependent growth of many breast tumours 18 , we proposed that E-cadherin represses the ESR1GRPR axis across tissues, including breast cancer

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