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Interventions in renal IR revolve around either reducing metabolic demand or enhancing mitochondrial repair: hypothermia is protective in kidney (surgeons often externally cool kidneys during temporary occlusion if possible, as lower temperature slows mitochondrial respiration and ROS)

doi: 10.1111/j.1365-2036.2008.03824.x

doi: 10.1152/ajplung.1997.272.1.L148

GLP-1RAs reduce the accumulation of advanced glycation end-products (AGEs), which bind to the receptor for AGEs (RAGE), and trigger pro-inflammatory pathways that contribute to lung pathology [130,131,132,133,134]

Any change in the COMT gene may cause the body to be slower to deactivate and expel these chemicals, which can lead to changes in stress reactions