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They found a total of 544 articles, but once duplicate articles were taken out, only 36 studies remained

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Gallbladder events : As with other incretin-based therapies, there is a potential risk of gallbladder disease, including cholelithiasis (gallstones)

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The coefficient of variation for orforglipron plasma exposure (AUC and Cmax) across Phase 1 studies was moderate and consistent with typical oral small-molecule drugs, whereas oral semaglutide shows substantially higher variability due to the sensitivity of SNAC-mediated gastric absorption to physiological factors including gastric pH, motility, and volume