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Plant polysaccharides also can inhibit upstream transcriptional factor Nrf2 expression, to suppress its downstream target proteins including HO-1, SLC7A11, and GPX4, ultimately leading to cancer cell death (Wang et al., 2024b)

In the November 2018 final rule (83 FR 59959 through 59964), we finalized changes to the beneficiary voluntary alignment policies (refer to 425.402(e)) to revise the requirements previously established for the voluntary alignment process

High intake of UPFs may cause dysfunction of the metallothionein genes and suppression of the paraoxonase-1 gene (PON1) (151)

191 Snail and Slug can competitively bind to the E-box sequence of the proximal promoter of E-cadherin gene with SMAD-associated protein 1 (SIP1), thereby inhibiting the expression of E-cadherin and inducing EMT in cells

thus temperate species could be suitable surrogates for understudied Arctic species