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What to Expect in Month 1 Appetite changes: Noticeable suppression begins week 3-4 for most Mild nausea: 40% experience some nausea, usually mild Injection site reactions: Redness, itching, or mild pain at injection site (14% of patients) Fatigue: Some patients report low energy as body adjusts Bowel changes: Either constipation or looser stools as medication affects gut motility 4 Essential Strategies for Month 1 1

Along with the progression of liver and digestive diseases to liver, colorectal and pancreatic cancer, the onset of inflammation in diseases of the digestive tract, drug-induced liver injury, and cholestasis, drives and contributes to the rise of these diseases in the future, which merit the attention of clinical and translational research to increase our understanding of the pathogenic mechanisms underlying these disorders in order to improve the diagnosis, management, and treatment

doi: 10.1007/s10549-010-1089-3 520 SiegelRMaJZouZJemalA