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Moreover, few high-quality pediatric trials exist, leaving major uncertainties regarding both efficacy and safety (7079)

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Auraptene, a monoterpene coumarin, inhibits LTA-induced inflammatory mediators via modulating NF-B/MAPKs signaling pathways

Rare, potentially severe adverse effects reported after single large overdoses include confusion, stupor, seizures, lactic acidosis, rhabdomyolysis, coma, and multiorgan failure that can be fatal

Induction of pyruvate carboxylase can allow tumor cells to use glucose-derived pyruvate instead of glutamine for anaplerosis, inducing a glutamine-independent growth [106-108]