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6.2.1.3 LRRK2 kinase inhibitors: from mechanism to clinical translation As an important direction in potential treatment strategies for PD, inhibitors targeting the LRRK2 kinase have attracted significant attention in recent years

A single exposure of doxorubicin between 0 and 50 M, yields minimal cytosolic GSH depletion (2.5% maximum decrease), which recovers within the prescribed time-span (Fig

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Mutation of Tyr 180 to Ala reduced activity by ~80%, even though the side chain is far from the active site, so it is unlikely that Tyr 180 is involved in catalysis