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The starting conformations were obtained by manually binding GS(H) to a snapshot of the MD simulation of TRaQ-G and the crystal structure of MeTRaQ-G, respectively

The first and rate-limiting step, catalyzed by glutamate-cysteine ligase (GCL), generates -glutamylcysteine from glutamate and cysteine

Li L, Su Z, Zou Z, Tan H, Cai D, Su L, et al

doi: 10.1210/er.2013-1058 20 SagoeDTorsheimTMoldeHAndreassenCSPallesenS

Results: Between April 2018 and December 2022, of 6516 patients with cirrhosis who reported to the nodal centre, we enrolled 1152 with decompensated cirrhosis (mean age:53.211.5 y, 62.9% men, median MELDNa 18.5,73.5%-unsafe injection related,77.9% urban)