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International Journal of Medicinal Mushrooms, 14 (6), 55761

This could primarily be allocated to the pivotal role of insulin in regulating carbohydrate and lipid metabolisms, but also to the involvement of many of these intermediates in bidirectionally modulating insulin production and signaling (e.g., influence of hyperglycemia in the development of IR, lipotoxicity induced by acyl-carnitines and FFAs) [4]