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But instead of producing a single change, berberine interacts with multiple targets, impacting more than one disease at a time

This specific lactylation event is crucial for maintaining the activity of neuronal networks and for stabilizing synaptic structures, highlighting its essential role as a mediator in the anxiolytic effects of exercise [192]

These structural differences are the basis for comparative structure-activity relationship studies examining how substitution pattern influences adrenergic receptor subtype selectivity and binding affinity across the phenylethanolamine compound series.

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