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SKU: 51525495509
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This AT-specific ER stress directly impairs insulin signaling by promoting c-Jun N-terminal kinase (JNK)-mediated serine phosphorylation of insulin receptor substrate (IRS-1), reducing glucose uptake capacity by up to 60% (101)

Hand PA, Inskip A, Gilford J, Alldersea J, Elexpuru-Camiruaga J, Hayes JD et al

& Nanau, R

To verify this hypothesis, we upregulated the expression of VRK2 in PC cells (PANC-1 cells and BxPC-3 cells) and examine the expression of SLC7A11 at whole cell and PM levels