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An imbalance exists between the production of ROS and the capacity of antioxidants within the cell gives rise to oxidative stress, a condition linked to irreversible cellular damage that ultimately causes hearing loss due to auditory impairment (Wang and Puel 2018)

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Doi: Salehi A, Faizi M, Belichenko PV, Mobley WC (2007) Using Mouse Models to Explore Genotype-Phenotype Relationship in Down Syndrome