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This imbalance of more free radicals than antioxidants is known as oxidative stress and has been associated with numerous health problems

Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimers disease

4.3 Combination therapies and novel drug delivery systems Given the multifactorial nature and complexity of OA pathogenesis, combination therapy strategies are generally considered to have greater advantages and potential than single-target interventions

Taken together, our results provide a mechanistic rationale for KEAP1NRF2-targeted interventions in MIBC and highlight how abrogating tumor antioxidant defenses and cell plasticity can synergize with conventional chemotherapy to yield superior anticancer effects