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Several similar processes were observed in the course of the associative analysis of biological processes

On chromosome 1, we observed a significant number of associated variants near the TMCO1 gene, which has been implicated in various disorders, including POAG, craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 25

This is another reason why higher concentrations (10-20mg/mL) are preferred for higher doses, and why the reconstitution charts emphasize these concentrations for the escalation and maintenance phases

Additional published animal studies indicate that acetaminophen exposure in utero adversely impacts reproductive capacity of both male and female offspring at clinically relevant exposures [see NONCLINICAL TOXICOLOGY (13.1)]