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As indicated in the CY 2025 PFS proposed rule, and as discussed above, CMS will monitor the extent to which manufacturers obtain a new NDC-9 for the same Part D rebatable drug in a manner that could result in inappropriately resetting the payment amount benchmark period or otherwise affect the calculation of the benchmark period manufacturer price

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After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return. These effects usually ease during the four-week hold

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