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[,,] Hepcidin interacts with the extracellular domain of ferroportin on cell membrane, resulting in internalization and degradation of ferroportin, effectively preventing cellular iron export and limiting the amount of iron that gets into serum or extracellular fluid

doi: 10.3389/fendo.2024.1427069 Received 07 May 2024 Accepted 21 August 2024 Published 11 September 2024 Volume 15 - 2024 Edited by Martine Culty, University of Southern California, United States Reviewed by Jasmina Zivanovic, University of Belgrade, Serbia Recep Hakki Koca, Bingl University, Trkiye Updates Copyright 2024 Pilsova, Pilsova, Zelenkova, Klusackova, Chmelikova, Postlerova and Sedmikova

AIM2 has been suggested to play roles in several cancers, and the TRIM11-p62-autophagy axis attenuated AIM2 signaling

These include zinc, magnesium, vitamin B6 or P-5-P, methionine, N-acetylcysteine (NAC), and creatine

(PubMed) However, while some small studies report mild pigment/lightening changes with glutathione (oral or topical), the clinical evidence for long-term, safe, and effective skin-whitening via IV glutathione is weak or absent