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SOD1 WT misfolding has been shown to occur in the spinal cord of sporadic (sALS) and non-SOD1 fALS patients 13,14,18,19,20,21,22,23 , and it was proposed that misfolded SOD1 WT and mutant proteins (SOD1 MUT ) share a common pathogenic pathway in ALS 18,23,24

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