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I.KleanthousH.CoverT

Methods The optimized pranlukast-containing amorphous solid dispersion, developed using design of experiments (DOEs), was evaluated for its pharmaceutical and biopharmaceutical properties through various analytical methods, including hot-stage microscopy, thermogravimetric analysis, differential scanning calorimetry, solubility measurement in polymer-containing aqueous solutions, Fourier transform infrared spectroscopy, powder X-ray diffraction (PXRD), dissolution testing, and in vivo pharmacokinetic (PK) studies

Boitani C, Puglisi R

doi:10.1002/ptr.6848

engineered a peptide derived from the amino acid sequence surrounding the C272 site of PD-L1, which competitively inhibited the palmitoylation of endogenous PD-L1 by ZDHHC3, thereby diminishing PD-L1 expression in tumour cells and enhancing T-cell-mediated antitumour immunity [55]