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Mechanisms controlling cellular and systemic iron homeostasis

Pharmaceutical companies have invested hundreds of millions of dollars in developing disease-modifying drugs, including monoclonal antibodies, inhibitors (e.g., aducanumab, donanemab, donepezil, memantine), while neurologists, psychiatrists, foundations, families, and affected individuals continue to await a transformative therapeutic breakthrough (Knopman et al., 2021)

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The PZQ LD 50 for NTS was determined after just 24 h exposure using both the Cell TiterGlo (27.1 2.27 M, Table 2) and the phenotypic analysis (42.9 0.83 M, Supplementary Movie 2), which is also used by others 54