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IECs contribute to the formation of the chemical barrier through the secretion of ROS and other substances [139]

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Taken together, these observations point to a future therapeutic paradigm that is inherently combinatorial: mitigation of metabolic and inflammatory stressors, protection and regeneration of endogenous -cells, and, where necessary, -cell replacement, complemented by targeted modulation of the gut microbiota

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Y., Jeney, G., & Yin, G