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As a powerful antioxidant, melatonin scavenges toxic free radicals (ROS/RNS) and prevents oxidative damage of DNA through activation of DNA repairing pathways 658

Those changes were said to be modified by the cholesterol levels in the circulation (Bjrkhem et al., 2006

Palmer KR, Mockler JC, Davies-Tuck ML, Miller SL, Goergen SK, Fahey MC, Anderson PJ, Groom KM, Wallace EM (2019) Protect-me: a parallel-group, triple blinded, placebo-controlled randomised clinical trial protocol assessing antenatal maternal melatonin supplementation for fetal neuroprotection in early-onset fetal growth restriction

Extract standardization, phytopharmacology of diverse extracts, characterization and isolation of active phytopharmaceuticals, clarification of isolated compound's mechanism of action and clinical trials of the compounds are all important in the creation of quality herbal medicine