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They form a complex network of interregulation through shared mitochondrial functional networks and oxidative stress signals

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Our team discovered this information only late in the piece, because the majority of literature on Gpx relates to Sec-Gpxs, which are more common in mammals

In in vitro experiments, GDNF treatment of midbrain dopaminergic neurons significantly increases mitochondrial DNA copy number and enhances mitochondrial membrane potentialan effect dependent on Ret-mediated activation of PGC-1 [75]