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Acknowledgements The authors thank Gong Meng and his colleagues from the metabolomics and proteomics platform of West China Hospital for their technical assistance, and Chen Haiyang and his colleagues from the Laboratory of Metabolism and Aging Research, West China Hospital, Sichuan University, and Wu Haoxing and his colleagues from Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, and Dr