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Currently, abnormal number and function of T lymphocyte subpopulations, the activation of inflammatory cytokines and the pathological loss of cell histology in the pathogenesis of gouty arthritis are closely linked to the extensive release of free radicals following oxidative stress

This work represents one of the next major advances in that progression, says Giovanni Traverso, director of the Laboratory for Translational Engineering and an associate professor of mechanical engineering at MIT, a gastroenterologist at Brigham and Womens Hospital, an associate member of the Broad Institute, and the senior author of the study

These anatomical features of SC degeneration are likely to reflect an altered composition of SC due to an impairment of autophagy-dependent protein turnover, which affects SC biosynthesis and elongation