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The authors emphasize the need to outline some indications for its use in order to reduce the consequences, among them are the people known to be subject to oxidative stress (Dotan et al., 2009)

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In recent years, several evidences have established the role of mTORC1 as a central regulatory node in such events, which coordinates energy consumption by the translation apparatus and ATP production in mitochondria (65) (Figure 2)

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