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Methods: We conducted the largest multi-ancestry genome-wide meta-analysis of all-cause cirrhosis and HCC, including 35,481 cirrhosis cases and 1,914,739 controls, as well as 7,126 HCC cases and 1,757,505 controls from large biobanks including as the Million Veteran Program (MVP), Copenhagen Hospital Biobank, UK Biobank, FinnGen, DeCODE, BioBank Japan, BioVU, AllofUS, and Penn Medicine Biobank