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During operation, heat is transferred from the internal circuit, through the coil to the spray water, and then to the atmosphere as a portion of the water evaporates

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237,238 AGEs accumulate in peripheral nerves and interact with the receptor for AGEs (RAGE) on cell surfaces, activating intracellular signaling pathways involving NF-B

We have shown previously that sirtuins SIRT1 and SIRT3 have anti-fibrotic function, and their decreased tissue expression observed in skin biopsies from SSc patients, might directly contribute to the persistence of fibrosis 28,29

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