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Description

Nat Med 14(2):194

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Immunohistochemistry analysis indicated that chemotherapy-resistant patients had significantly higher expression levels of NRF2, GPX4 and SOD1 in tumor tissues compared to the sensitive ones

Institute of, The National Academies Collection

This reliance of NSCs on proper NRF2 function was further confirmed using an Nrf2 / mouse, which exhibited fewer SVZ NPCs than wild-type mice, with surviving Nrf2 / NSCs proliferating less and exhibiting decreased neurogenic potential (Corenblum et al., 2016