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Combining these approaches with in vivo shear stress modeling could provide insights into how oscillatory flow drives proinflammatory EC phenotypes via mechanosensitive pathways

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Calculation of the risk score was performed as follows: Risk score=e(0.279 TFR2 expression level + 0.113 RGS4 expression level + 0.011 ZFP36 expression level) (Table SII)

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They also note that the same polymorphisms of glutamate receptors: have also been associated with a number of neuropsychiatric disorders including autism, Huntingtons disease, ADHD, OCD The authors conclude that Replication of these findings will open novel avenues for the study of CFS pathogenesis Research into the genetics of Huntingtons disease suggest that a combination of polymorphisms in the GRIK2 gene and PPARGC1A (also called PGC1-alpha the master regulator of mitochondrial biogenesis and function) may determine the age of onset of the disease (Gusella, Macdonald, 2009)