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[78] [79] The reaction of transition metals with proteins oxidated by reactive oxygen or nitrogen species can yield reactive products that accumulate and contribute to aging and disease

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GSK-3, a key Akt target, has multiple functions, including regulating cell proliferation, apoptosis, glycogen metabolism, and stem cell renewal ( The Nrf2-Keap1-ARE signaling axis plays a crucial role in antioxidant defense and is also effective in defense against tumor development

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