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Interestingly, single nucleotide polymorphisms in the IL-1, IL-6 and IL-10 genes have been associated with cachexia in gastrointestinal cancers ( The identification of these cytokines as central players in cachexia led to the development of therapeutic strategies focusing on their targeting (Monk et al., 2006

1 Introduction Dry Eye Disease (DED) is a complex, chronic ocular surface disease arising from diverse etiologies, significantly impacting quality of life (Figure 1) (Liu et al., 2022

doi: 10.1016/j.celrep.2019.03.038 12 GrabeV.EgelandsdalB.KjosN

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They continued their life in the Houston area where they raised two children