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Poster session II - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P929 - ESOC25-2149 IMPACT OF THE ICD-11 DEFINITION ON STROKE INCIDENCE RATES AND 3-MONTH OUTCOMES: A 2-YEAR EVALUATION OF THE SOUTH LONDON STROKE REGISTER (2022-2024) Camila Pantoja Ruiz 1 , Eva Emmett 1 , Abdel Douiri 1 , Ajay Bhalla 1 , Charles Wolfe 1 , Yanzhong Wang 1 , Matthew Dl Oconnell 1 , Martin Chapman 1 , Iain Marshall 1 1 Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom Background and Aims: The World Health Organizations ICD-11 redefined stroke including symptoms lasting 1 at 3 months

At the same time, the field acknowledges real limitations heterogeneous trial designs, industry-funded studies, and copper's inherent toxicity at higher concentrations that responsible researchers should factor into any study design

62 In addition to their ability to generate HETEs via a similar process as described above for 5-LOX, 12-LOX and 15-LOX also generate LXs, oxo-ETEs, and dihydroxyeicosatetraenoic acids (diHETEs)

Agents such as pembrolizumab and dostarlimab, particularly in combination with carboplatin and paclitaxel, have improved progression-free and overall survival rates for patients with MMR-deficient tumors