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1be, 2b, 3d, 4c, 5, as well as Supplementary Figs 1d, 2a, b, and 9 can be found in the Supplementary DataSet, with sheet tabs labelled according to the corresponding figure number

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Materials and methods Samples collection and ethical approval A total of 20 paraffin-embedded CRC primary tumor samples were obtained from the Department of Pathology of Nanfang Hospital, Southern Medical University, Guangzhou, China