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Add-ons Antioxidants like glutathione, amino acids like taurine and carnitine, fat-metabolism cofactors like MIC (methionine, inositol, choline), and specialty molecules like NAD+

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Advancement in the knowledge about lipids, peptides, aptamers, antibodies, and sugars would help in improving bio-conjugation of nucleic acid therapeutics with these moieties, which shall in turn promote intracellular uptake, targeting specific cells/tissues or reduce clearance from the circulation

Their acquisition of iron from heme in blood would generate increasing amounts of formaldehyde, necessitating for the RuMP based detoxification system