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Traditional Chinese Medicine (TCM), with its personalized and modernized approach combining oral administration and external treatments like acupuncture, enema, and nanodelivery, targets fatty acid metabolism to improve RF, offering unique advantages such as a multi-targeted approach, reduced toxicity, enhanced efficacy, and minimal side effects

[193] [194] In addition, serotonin releasing agents (SRAs), including appetite suppressants like fenfluramine and chlorphentermine and entactogens like MDMA, elevate serotonin levels and indirectly activate serotonin 5-HT 2A receptors similarly

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Future investigations should prioritize large-scale, multi-center randomized clinical trials with extended follow-up periods

Hala A, Khattab Z, Abdallah G, Kamel M