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67 Plasma levels of selenium are low in patients with COPD, and a similar trend towards low plasma selenium has been reported in individuals homozygous for the ZZ alpha-1 antitrypsin genotype

Regulation of ACSL4 and LPCATs may determine susceptibility to ferroptosis [54,55,56,57,58,59,60,61]

Lung exposure to infectious agents like Porphyromonas , Epstein-Barr virus, and gingivitis, along with noxious agents, dietary factors, and the gut microbiome, also contribute to ACPA generation (50)