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3.3 Functional and mechanistic studies of phytochemical anti-inflammatory based on zebrafish models 3.3.1 Anti-inflammatory functions of phytochemical anti-inflammatory Zebrafish inflammation models have evolved into a multidimensional evaluation system encompassing whole-organism behavior, tissue-level pathology, and molecular mechanisms, thus providing a robust in vivo platform for systematic assessment of the anti-inflammatory efficacy of phytochemicals (Xie et al., 2020)

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[1][2] NR (nicotinamide riboside): In a randomized, double-blind, placebo-controlled trial in adults ages 55 to 79, 500 mg twice daily for six weeks raised NAD+ levels in peripheral blood mononuclear cells by about 60%

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Additionally, interest in LPL has been reinforced over the past decade by its great pathophysiological relevance in the abovementioned diseases and in other contexts of disordered lipid metabolism such as severe hypertriglyceridemia and the potentially associated acute pancreatitis, as well as in non-alcoholic fatty liver disease (NAFLD) [9]

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