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Privalov revealed in 1983 that intrinsically disordered histones H1 and H5 (defined by these authors as denatured random coil proteins) can partially fold in the presence of salt, with folding taking place within their N-terminal 80-residue-long fragments that can be derived from both proteins by trypsin digestion in high salt (Crane-Robinson and Privalov, 1983)

Dec 19 2022;11(24)doi:10.3390/jcm11247524