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Furthermore, IGF-1 mediates many growth hormones (GH) actions

Chen, M., Huang, J., Yang, X., Liu, B., Zhang, W., Huang, L., Deng, F., Ma, J., Bai, Y., Lu, R., Huang, B., Gao, Q., Zhuo, Y., & Ge, J

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Because bile salts are required to keep cholesterol dissolved in bile, their loss through the gastrointestinal tract leads to cholesterol supersaturation and stone formation