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In clinical trials, CDDO-Me demonstrated antitumor activity in phase 1 for advanced solid tumors and lymphoma [279]

[PubMed: 13716236] 192

Released SEMA3C binds to neuropilin-1 (NRP1) and integrin 1 (ITG1) receptors on hepatic stellate cells (HSC), triggering NF-B signaling

Additionally, the cardiac magnetic resonance substudy of the SUMMIT trial revealed that compared with placebo, tirzepatide treatment of obese HFpEF patients reduced the LV mass and paracardial adipose tissue volume, with the changes in the LV mass paralleling the degree of weight loss [166]

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