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doi: 10.3389/fped.2024.1496846 Received 15 September 2024 Accepted 25 November 2024 Published 23 December 2024 Volume 12 - 2024 Edited by Raul Chavez-Valdez, Johns Hopkins Medicine, United States Reviewed by Johana Diaz, University of Maryland, United States Jennifer Fundora, Johns Hopkins University, United States Updates Copyright 2024 Chamakioti, Brion, Viswanathan, Lair and Angelis

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Dephosphorylation of fructose-1,6-bisphosphate back to fructose-6-phosphate does not occur, considering that in most cancers the expression of fructose-1,6-bisphosphatase is strongly diminished 117

For example, the silent information regulator 1 (SIRT1), a NAD + -dependent protein deacetylase, functions as a key upstream regulator for LKB1/AMPK signaling in the liver 50

Antioxidant supplementation supports both preventative strategies against photoaging and recovery after procedures that transiently increase oxidative stress, such as laser resurfacing